DETAILED NOTES ON XYLAZINE AND KETAMINE

Metabolism Ketamine is metabolized by means of N-dealkylation towards the Energetic metabolite norketamine primarily by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation in the cyclohexone ring to form hydroxynorketamine compounds by means of CYP-dependent pathways, which are conjugated with glu